This activity is designed for psychiatrists, primary care physicians, physician assistants, advanced practice nurses, advanced practice psychiatric nurses and other healthcare professionals who desire to improve their diagnostic and treatment skills, and advance their knowledge of major depressive disorder

• Describe the role of glutamatergic and neuroplasticity-based strategies in informing first-line treatment approaches for MDD 
• Apply current evidence for newly approved and emerging treatments to personalize early-stage management of MDD 
• Evaluate evidence-based augmentation approaches for patients with partial response, including pharmacologic and non-pharmacologic options 
• Implement practical methods to enhance adherence, tolerability, and persistence through real-world strategies and lifestyle integration 
• Use evidence-driven approaches for treatment sequencing and maintenance to achieve remission and sustain long-term functional recovery